As one of 725 UNESCO World Heritage Properties, Antigua, Guatemala, is subject to local international regulations related to building codes and how streets and public places are occupied. These regulations are discussed within the theoretical framework of spatial governmentality to explore that relationship between governance and Maya street vendors’ economic practices. I situate the scholarly discussion of spatial governmentality within a specific economic context by highlighting how street economies are affected by what Foucault calls the “era of ‘governmentality,’” especially in an ethnographic context. In this article, I argue that horizontal and vertical forms of governmentality affect the economic practices of street vendors within Antigua’s sociopolitically constructed spaces. Understanding how spatial governmentalities work in a particular place helps explain why street economies persist and why new ones emerge. In Antigua’s case, a new mobile form of street vending emerged because of newly implemented municipal regulations and policing priorities.